Here, we investigated the contribution of gut microbiota to chemoresistance in patients with colorectal cancer ; ARTICLESwitch to Standard View Fusobacterium nucleatum Promotes Chemoresistance to Colorectal Cancer by Modulating Autophagy

Highlights •Specific gut microbes track with post-chemotherapy recurrence of colorectal cancer •F. nucleatum orchestrates the Toll-like receptor, microRNAs, and autophagy network to control cancer chemoresistance •Measuring and targeting F. nucleatum may be useful for patient prognosis and management Summary Gut microbiota are linked to chronic inflammation and carcinogenesis. Chemotherapy failure is the major cause of recurrence and poor prognosis in colorectal cancer patients. . We found that Fusobacterium (F.) nucleatum was abundant in colorectal cancer tissues in patients with recurrence post chemotherapy, and was associated with patient clinicopathological characterisitcs. Furthermore, our bioinformatic and functional studies demonstrated that F. nucleatum promoted colorectal cancer resistance to chemotherapy. Mechanistically, F. nucleatum targeted TLR4 and MYD88 innate immune signaling and specific microRNAs to activate the autophagy pathway and alter colorectal cancer chemotherapeutic response. Thus, F. nucleatum orchestrates a molecular network of the Toll-like receptor, microRNAs, and autophagy to clinically, biologically, and mechanistically control colorectal cancer chemoresistance. Measuring and targeting F. nucleatum and its associated pathway will yield valuable insight into clinical management and may ameliorate colorectal cancer patient outcomes. Keywords: Colorectal cancer, recurrence, chemoresistance, F.nucleatum, autophagy, Toll-like receptor, miRNA To access this article, please choose from the options below Log In Login to existing account Forgot password? Register Create a new account Read-It-Now Now available: purchase access to all research journal HTML articles for 6 or 36 hours. Click here to explore this opportunity. Purchase Access to this Article PDF Download and 24 Hours Online Access Claim Access If you are a current subscriber with Society Membership or an Account Number, claim your access now. Subscribe to this Journal Purchase a subscription to gain access to this and all other articles in this journal.